BDBM142601 US8933228, 3

SMILES Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c3ccccc23)cc1

InChI Key InChIKey=JIFZZVZROIFPKB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 142601   

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 142601BDBM142601(US8933228, 3)
Affinity DataIC50: 1nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
US Patent

TargetTyrosine-protein kinase HCK(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 142601BDBM142601(US8933228, 3)
Affinity DataIC50: 2nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 142601BDBM142601(US8933228, 3)
Affinity DataIC50: 4nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase 12(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 142601BDBM142601(US8933228, 3)
Affinity DataIC50: 24nMAssay Description:The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 142601BDBM142601(US8933228, 3)
Affinity DataIC50: 26nMAssay Description:Inhibition of BRAF V600E mutant ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 142601BDBM142601(US8933228, 3)
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of human BRAF V600E mutant expressed in baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed