BDBM142754 US8937193, 6f

SMILES Cc1ccc(CCc2c(O)c(O)cc3c2c(=O)c(C)c(-c2c(C)c(=O)c4c(CCc5ccc(C)cc5)c(O)c(O)cc4c2=O)c3=O)cc1

InChI Key InChIKey=KPHBSOQOTONLSS-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 142754   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM142754(US8937193, 6f)
Affinity DataIC50: 2.05E+3nMT: 2°CAssay Description:A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM142754(US8937193, 6f)
Affinity DataKd:  2.50E+3nMAssay Description:The synthesized compounds of Formula I may be screened by one-dimensional 1H nuclear magnetic resonance spectroscopy (1D-1H NMR) binding assays again...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM142754(US8937193, 6f)
Affinity DataIC50: 3.10E+3nMT: 2°CAssay Description:A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM142754(US8937193, 6f)
Affinity DataIC50: 3.12E+3nMT: 2°CAssay Description:A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
US Patent

TargetBcl-2-related protein A1(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM142754(US8937193, 6f)
Affinity DataIC50: 1.47E+4nMT: 2°CAssay Description:A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR (SEQ ID NO:1)) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2015
Entry Details
US Patent