BDBM14429 4-({3-[(3-chlorophenyl)methyl]-1-methyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl}(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile::benzimidazolone analog 13c

SMILES Cn1cncc1C(O)(c1ccc(cc1)C#N)c1ccc2n(C)c(=O)n(Cc3cccc(Cl)c3)c2c1

InChI Key InChIKey=POSJESMMMMOKRK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14429   

LigandPNGBDBM14429(4-({3-[(3-chlorophenyl)methyl]-1-methyl-2-oxo-2,3-...)
Affinity DataIC50: 5.20nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14429(4-({3-[(3-chlorophenyl)methyl]-1-methyl-2-oxo-2,3-...)
Affinity DataIC50: 5.60E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed