BDBM14597 2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-biphenyl-2-yl]-N-{4-[amino(imino)methyl]benzyl}acetamide::2-[6-(3-aminophenyl)-2-fluoro-3-(propan-2-ylamino)phenyl]-N-[(4-carbamimidoylphenyl)methyl]acetamide::CHEMBL125781::Substituted Benzene Analog 50c

SMILES CC(C)Nc1ccc(-c2cccc(N)c2)c(CC(=O)NCc2ccc(cc2)C(N)=N)c1F

InChI Key InChIKey=UIFFGJRELUIVDZ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 14597   

TargetCoagulation factor VII(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 340nMAssay Description:Inhibitory activity against tissue coagulation factor VIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 340nMAssay Description:Inhibition of recombinant human soluble tissue factor (1 to 219 residues) expressed in Escherichia coli/recombinant human factor 7a using N-methylsul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 340nMAssay Description:Inhibition of factor 7aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 340nMpH: 8.0 T: 2°CAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 340nMAssay Description:Inhibition of human factor 7a using H-Dphenylalanyl-L-pipecolyl-L-arginine-p-nitroaniline dihydrochloride as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 950nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 950nMAssay Description:Inhibition of human factor 2a using H-Dphenylalanyl-L-pipecolyl-L-arginine-p-nitroaniline dihydrochloride as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 950nMAssay Description:Inhibition of human thrombin using H-D-phenylalanyl-L-pipecolyl-L-arginine-p-nitroaniline dihydrochloride as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 950nMpH: 8.0 T: 2°CAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human factor 10a using N-alpha-benzyloxy-carbonyl-D-arginyl-L-glycyl-L-arginine-p-nitroaniline-dihydrochloride as substrate after 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 3.00E+4nMpH: 8.0 T: 2°CAssay Description:Human Factor Xa and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed