BDBM146053 US8957068, 88

SMILES CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(F)cc2)n1

InChI Key InChIKey=JQRQRZHDVNMQMO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 146053   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM146053(US8957068, 88)
Affinity DataIC50: 150nMAssay Description:Inhibition of human N-terminal 6His-tagged IDH1 R132H mutant expressed in Escherichia coli Rosetta2 (DE3) assessed as effect on intracellular 2-HG le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM146053(US8957068, 88)
Affinity DataIC50: 246nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM146053(US8957068, 88)
Affinity DataIC50: 350nMAssay Description:Inhibition of IDH1 R132H mutant expressed in human HCT-116 cells assessed as effect on intracellular 2-HG level incubated for 48 hrs by LC/MS/MS anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed