BDBM14647 (3Z)-5-(4-hydroxy-3-methoxyphenyl)-3-[(7-methyl-1H-indol-3-yl)methylidene]-2,3-dihydro-1H-indol-2-one::indolinone analog 11

SMILES COc1cc(ccc1O)-c1ccc2NC(=O)\C(=C/c3c[nH]c4c(C)cccc34)c2c1

InChI Key InChIKey=KDBCXBKEISUEMH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14647   

TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

LigandPNGBDBM14647((3Z)-5-(4-hydroxy-3-methoxyphenyl)-3-[(7-methyl-1H...)
Affinity DataIC50: 3.47E+3nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed