BDBM14705 1,3-diethyl 2-[(1H-1,3-benzodiazol-5-ylamino)methylidene]propanedioate::2-[(1H-Benzimidazol-5-ylamino)-methylene]-malonic acid diethyl ester::bicyclic compound 10

SMILES CCOC(=O)C(C=Nc1ccc2nc[nH]c2c1)C(=O)OCC

InChI Key InChIKey=ATOLSPMCHQAEIO-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14705   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14705(1,3-diethyl 2-[(1H-1,3-benzodiazol-5-ylamino)methy...)
Affinity DataKi:  4.02E+4nM ΔG°:  -5.99kcal/mole IC50: 3.49E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
LigandPNGBDBM14705(1,3-diethyl 2-[(1H-1,3-benzodiazol-5-ylamino)methy...)
Affinity DataIC50: 5.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed