BDBM148178 US8962616, 6

SMILES C[C@H]1SC(N)=N[C@]2(CO[C@H](C[C@@H]12)c1ncco1)c1ccc(F)cc1F

InChI Key InChIKey=UVLZAXVMVHTAGW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148178   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM148178(US8962616, 6)
Affinity DataIC50: 198nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Pfizer

US Patent
LigandPNGBDBM148178(US8962616, 6)
Affinity DataIC50: 2.37E+3nMpH: 4.5 T: 2°CAssay Description:This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent