BDBM14863 ({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2-hydroxyphenyl]-4-hydroxyphenyl}methyl)urea::5-amidinobenzimidazole analog 1::CHEMBL378916

SMILES NC(=O)NCc1ccc(O)c(c1)-c1cccc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O

InChI Key InChIKey=AEOYTBFWYXDAMX-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 14863   

TargetCoagulation factor VII(Human)
Celera

LigandPNGBDBM14863(({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2...)
Affinity DataKi:  13nM ΔG°:  -10.6kcal/molepH: 7.4 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Human)
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM14863(({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2...)
Affinity DataKi:  13nMAssay Description:Binding affinity to f7a/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Human)
Celera

LigandPNGBDBM14863(({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2...)
Affinity DataKi:  14nMAssay Description:Binding affinity to f7aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Celera

LigandPNGBDBM14863(({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2...)
Affinity DataKi:  2.70E+3nM ΔG°:  -7.52kcal/molepH: 7.4 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Human)
Celera

LigandPNGBDBM14863(({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2...)
Affinity DataKi:  2.70E+3nMAssay Description:Binding affinity to f10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14863(({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2...)
Affinity DataKi:  3.60E+3nM ΔG°:  -7.35kcal/molepH: 7.4 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Celera

LigandPNGBDBM14863(({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2...)
Affinity DataKi:  9.00E+4nM ΔG°:  -5.46kcal/molepH: 7.4 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Human)
Celera

LigandPNGBDBM14863(({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2...)
Affinity DataKi:  9.00E+4nMAssay Description:Binding affinity to thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed