BDBM149858 US8975415, RP139::US9242973, RP139

SMILES CC1(C)Oc2ccc(cc2C2(COC(N)=N2)C11COC1)-c1cccc(Cl)c1

InChI Key InChIKey=ZEAMOJNDSBWBMU-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 149858   

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149858(US8975415, RP139 | US9242973, RP139)
Affinity DataIC50: 140nMT: 2°CAssay Description:Test Example 3: The potency of compounds against BACE1 activity was determined in a cellular assay of Aβ production. Human SK-N-BE(2) neuroblast...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149858(US8975415, RP139 | US9242973, RP139)
Affinity DataKi:  215nM ΔG°:  -9.09kcal/mole IC50: 252nMpH: 4.4 T: 2°CAssay Description:Test Example 1: Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Comentis

US Patent
LigandPNGBDBM149858(US8975415, RP139 | US9242973, RP139)
Affinity DataKi:  215nM IC50: 252nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
US Patent