BDBM15152 1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one::pyrazinone 13b

SMILES Cc1nc(-c2ccc(CN3CCC(n4c(=O)[nH]c5ccccc54)CC3)cc2)c(-c2ccccc2)[nH]c1=O

InChI Key InChIKey=VQEYGNWUFJMZPZ-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15152   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 15152BDBM15152(1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...)
Affinity DataIC50: 760nMpH: 7.5 T: 2°CAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 15152BDBM15152(1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...)
Affinity DataKi:  760nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 15152BDBM15152(1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...)
Affinity DataIC50: 760nMAssay Description:Inhibition of AktMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 15152BDBM15152(1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...)
Affinity DataIC50: 2.40E+4nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandChemical structure of BindingDB Monomer ID 15152BDBM15152(1-(1-{[4-(6-methyl-5-oxo-3-phenyl-4,5-dihydropyraz...)
Affinity DataIC50: 5.00E+4nMAssay Description:Purified recombinant human Akt1, Akt2, and Akt3 proteins were monitored for kinase activity in the presence or absence of Akt inhibitors in a 96-well...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed