BDBM152964 US8993614, 26

SMILES COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@](C#N)([C@H]1c1cccc(Cl)c1F)c1ccc(Cl)cc1F)C(=O)OCOC(=O)NCC(=O)OCc1ccccc1.COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@](C#N)([C@H]1c1cccc(Cl)c1F)c1ccc(Cl)cc1F)C(=O)OC(C)OC(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1

InChI Key InChIKey=WYKATBMXKLFLGQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 152964   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM152964(US8993614, 26)
Affinity DataIC50: 5.82nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent