BDBM152980 BDBM152981::BDBM152982::US8993614, 45

SMILES COCCOCCNC(=O)OCOC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@@](C#N)([C@H]2c2cccc(Cl)c2F)c2ccc(Cl)cc2F)c(OC)c1

InChI Key InChIKey=JGHFHBOSDORGTB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 152980   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM152980(US8993614, 45 | BDBM152981 | BDBM152982)
Affinity DataIC50: 4.63nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM152980(US8993614, 45 | BDBM152981 | BDBM152982)
Affinity DataIC50: 30.3nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM152980(US8993614, 45 | BDBM152981 | BDBM152982)
Affinity DataIC50: 40.8nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent