BDBM15357 3-(2-methoxyphenyl)-1-naphthalen-1-ylurea::ChemBridge compound no. 12

SMILES COc1ccccc1NC(=O)Nc1cccc2ccccc12

InChI Key InChIKey=FWEMUPBSFQCOSI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15357   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15357(3-(2-methoxyphenyl)-1-naphthalen-1-ylurea | ChemBr...)
Affinity DataIC50:  230nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395](Homo sapiens (Human))
University of Texas Southwestern Medical Center

LigandPNGBDBM15357(3-(2-methoxyphenyl)-1-naphthalen-1-ylurea | ChemBr...)
Affinity DataIC50:  1.12E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))TBA
LigandPNGBDBM15357(3-(2-methoxyphenyl)-1-naphthalen-1-ylurea | ChemBr...)
Affinity DataIC50:  251nMAssay Description:Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectr...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [H185A](Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15357(3-(2-methoxyphenyl)-1-naphthalen-1-ylurea | ChemBr...)
Affinity DataIC50:  1.40E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [R265A](Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15357(3-(2-methoxyphenyl)-1-naphthalen-1-ylurea | ChemBr...)
Affinity DataIC50:  240nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed