BDBM15362 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethylbenzene-1,3-diol::CCT018159::CHEMBL399530::VER-00063579

SMILES CCc1cc(-c2n[nH]c(C)c2-c2ccc3OCCOc3c2)c(O)cc1O

InChI Key InChIKey=OWPMENVYXDJDOW-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15362   

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15362(VER-00063579 | 4-[4-(2,3-dihydro-1,4-benzodioxin-6...)
Affinity DataIC50: 280nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2007
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15362(VER-00063579 | 4-[4-(2,3-dihydro-1,4-benzodioxin-6...)
Affinity DataIC50: 280nM EC50:  5.80E+3nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMed
TargetATP-dependent molecular chaperone HSP82(Baker's yeast)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM15362(VER-00063579 | 4-[4-(2,3-dihydro-1,4-benzodioxin-6...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of yeast Hsp90 ATPase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetATP-dependent molecular chaperone HSP82(Baker's yeast)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM15362(VER-00063579 | 4-[4-(2,3-dihydro-1,4-benzodioxin-6...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of yeast Hsp90 ATPase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetATP-dependent molecular chaperone HSP82(Baker's yeast)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM15362(VER-00063579 | 4-[4-(2,3-dihydro-1,4-benzodioxin-6...)
Affinity DataIC50: 8.90E+3nMAssay Description:Binding affinity to yeast Hsp90 ATPase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed