BDBM15402 N-[4-hydroxy-3-(2-hydroxy-1-naphthalenyl)phenyl]benzenesulfonamide::N-[4-hydroxy-3-(2-hydroxy-1-naphthyl)phenyl]benzenesulfonamide::N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)phenyl]benzenesulfonamide::N-[4-oxidanyl-3-(2-oxidanylnaphthalen-1-yl)phenyl]benzenesulfonamide::cid_1073704::naphthol compound 5

SMILES Oc1ccc(NS(=O)(=O)c2ccccc2)cc1-c1c(O)ccc2ccccc12

InChI Key InChIKey=UUWGREFGSDPMIN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15402   

TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM15402(N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)phenyl]be...)
Affinity DataIC50: 3.30E+3nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2007
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM15402(N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)phenyl]be...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of Hsp90 in human SKBR3 cells assessed as interaction with Cy3b-conjugated geldanamycin by FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM15402(N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)phenyl]be...)
Affinity DataIC50: 1.30E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details
PCBioAssay