BDBM15494 3-{6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl}benzoic acid::CHEMBL236508::Pyrrolidine-constrained phenethylamine 29c

SMILES N[C@H]1CN(C[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)-c1cccc(c1)C(O)=O

InChI Key InChIKey=PAEWYHLNDGOPKM-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 15494   

TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM15494(CHEMBL236508 | 3-{6-[(3R,4S)-3-amino-4-(2,4,5-trif...)
Affinity DataKi:  1.80nMAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM15494(CHEMBL236508 | 3-{6-[(3R,4S)-3-amino-4-(2,4,5-trif...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Abbott Laboratories

LigandPNGBDBM15494(CHEMBL236508 | 3-{6-[(3R,4S)-3-amino-4-(2,4,5-trif...)
Affinity DataKi: >3.00E+3nMAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Abbott Laboratories

LigandPNGBDBM15494(CHEMBL236508 | 3-{6-[(3R,4S)-3-amino-4-(2,4,5-trif...)
Affinity DataKi: >3.00E+3nMAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2007
Entry Details Article
PubMed