BDBM155380 US9006282, Example 2, Compound 8::US9102656, Example 2, Compound 8

SMILES CC(C)c1nc(nc(-c2ccc(F)cc2)c1\C=C\[C@@H]1C[C@@H](O)CC(Oc2c(F)cc(F)cc2F)O1)N(C)S(C)(=O)=O

InChI Key InChIKey=MAPWRPSCIIWUDB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 155380   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
Redx Pharma

US Patent
LigandPNGBDBM155380(US9006282, Example 2, Compound 8 | US9102656, Exam...)
Affinity DataIC50: 1nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Redx Pharma

US Patent
LigandPNGBDBM155380(US9006282, Example 2, Compound 8 | US9102656, Exam...)
Affinity DataIC50: 1nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
US Patent