BDBM156575 US10118915, Compound 355::US20250346584, Compound 355::US9682966, 355

SMILES CCc1ccc2nc(N3CCC(CC3)NCC(C)C)c(cc2c1)-c1nc(C)no1

InChI Key InChIKey=JTFHVEYAVQAEGK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 156575   

LigandChemical structure of BindingDB Monomer ID 156575BDBM156575(US9682966, 355 | US10118915, Compound 355 | US2025...)
Affinity DataIC50: 1.20nMAssay Description:The IC50 of each compound shown in Table was with respect to the kappa opioid receptor was determined. The cell line for the OPRK1 antagonist assay s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 156575BDBM156575(US9682966, 355 | US10118915, Compound 355 | US2025...)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:The cell line for the OPRK1 antagonist assay stably expresses the following elements. The carboxy terminus of the OPRK1 receptor has a 7 amino acid l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 156575BDBM156575(US9682966, 355 | US10118915, Compound 355 | US2025...)
Affinity DataIC50: 1.20nMAssay Description:Well-known assay for kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 156575BDBM156575(US9682966, 355 | US10118915, Compound 355 | US2025...)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at GAL4-VP16-fused KOR (unknown origin) expressed in human U2OS cells co-expressing Tango-OPRK1-BLA assessed as inhibition of U-5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 156575BDBM156575(US9682966, 355 | US10118915, Compound 355 | US2025...)
Affinity DataIC50: 4.39E+3nMAssay Description:Antagonist activity at GAL4-VP16-fused MOR (unknown origin) expressed in human U2OS cells assessed as inhibition of DAMGO-induced beta-arrestin migra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 156575BDBM156575(US9682966, 355 | US10118915, Compound 355 | US2025...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at GAL4-VP16-fused DOR (unknown origin) expressed in human U2OS cells assessed as inhibition of DAMGO-induced beta-arrestin migra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed