BDBM15828 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-(1-cyclopropylpiperidin-4-yl)-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 13

SMILES Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)NC2CCN(CC2)C2CC2)no1

InChI Key InChIKey=XDHLEMSKBSBEDC-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15828   

TargetCoagulation factor X(Human)
Aventis Pharma Deutschland

LigandPNGBDBM15828(1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]meth...)
Affinity DataKi:  27nM ΔG°:  -10.3kcal/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Aventis Pharma Deutschland

LigandPNGBDBM15828(1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]meth...)
Affinity DataKi:  8.22E+3nM ΔG°:  -6.93kcal/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human thrombin was determined by using the chromogenic substrates S-2366. The hydrolysis rates of chromoge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2007
Entry Details Article
PubMed