BDBM160662 US9045498, 4

SMILES NC1=NC2(CO[C@@H](CF)C[C@H]2CS1)c1cc(C#N)c(F)cc1F

InChI Key InChIKey=LGJIPDMTLWEFJV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 160662   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM160662(US9045498, 4)
Affinity DataIC50: 854nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2016
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Pfizer

US Patent
LigandPNGBDBM160662(US9045498, 4)
Affinity DataIC50: 2.52E+3nMpH: 4.5 T: 2°CAssay Description:This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2016
Entry Details
US Patent