BDBM161032 US9108947, 2

SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CNC1(CCC1)C1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)C1

InChI Key InChIKey=MTJHXZSAFKGIMW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 161032   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM161032(US9108947, 2)
Affinity DataIC50: 420nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2016
Entry Details
US Patent