BDBM161094 US9051240, (S)-(+)-2-[4-(2-Fluorobenzyloxy)-benzylamino]-propanamide

SMILES C[C@H](NCc1ccc(OCc2ccccc2F)cc1)C(N)=O

InChI Key InChIKey=BHJIBOFHEFDSAU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 161094   

TargetAmine oxidase [flavin-containing] B(Rat)
Newron Pharmaceuticals

US Patent
LigandPNGBDBM161094(US9051240, (S)-(+)-2-[4-(2-Fluorobenzyloxy)-benzyl...)
Affinity DataIC50: 200nMpH: 7.4Assay Description:The enzyme activity was assessed with a radioenzymatic assay using the substrate 14C-phenylethylamine (PEA) specific for MAO-B.The mitochondrial pell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2016
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM161094(US9051240, (S)-(+)-2-[4-(2-Fluorobenzyloxy)-benzyl...)
Affinity DataIC50: 3.52E+4nMAssay Description:Inhibition of Nav1.7 (unknown origin) by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM161094(US9051240, (S)-(+)-2-[4-(2-Fluorobenzyloxy)-benzyl...)
Affinity DataIC50: 1.75E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed