BDBM161264 US11673864, Compound 49::US9051270, 49::US9758483, Compound 49

SMILES COc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1

InChI Key InChIKey=JNNYSEIQBAVVNL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 161264   

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161264(US9051270, 49 | US9758483, Compound 49 | US1167386...)
Affinity DataIC50: 24nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Rat)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161264(US9051270, 49 | US9758483, Compound 49 | US1167386...)
Affinity DataIC50: 24nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2016
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161264(US9051270, 49 | US9758483, Compound 49 | US1167386...)
Affinity DataIC50: 24nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent