BDBM161462 US10835536, Ref. Ex. Comp 3::US10894048, Ref. Ex Comp. 3::US9108973, Ref 3

SMILES CCC(=O)N1CC[C@@H](C1)n2c3c(c(n2)C#Cc4cc(cc(c4)OC)OC)c(ncn3)N

InChI Key InChIKey=DZLNAZQOANZLHT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 161462   

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161462(US9108973, Ref 3 | US10894048, Ref. Ex Comp. 3 | U...)
Affinity DataIC50: 190nMpH: 7.5 T: 2°CAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2016
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161462(US9108973, Ref 3 | US10894048, Ref. Ex Comp. 3 | U...)
Affinity DataIC50: 190nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161462(US9108973, Ref 3 | US10894048, Ref. Ex Comp. 3 | U...)
Affinity DataIC50: 190nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161462(US9108973, Ref 3 | US10894048, Ref. Ex Comp. 3 | U...)
Affinity DataIC50: 244nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161462(US9108973, Ref 3 | US10894048, Ref. Ex Comp. 3 | U...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human EGFR del19/T790M using biotinEEPLYWSFPAKKK-NH2 as substrate incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed