BDBM163115 US9062026, Table III, Compound 43

SMILES Cc1cc2ccccc2n1-c1nc2CCNCc2c(NCc2ccccc2)n1

InChI Key InChIKey=KEXDPSXGMWVJRT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 163115   

TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM163115(US9062026, Table III, Compound 43)
Affinity DataIC50: 192nMAssay Description:Inhibition of human p97 ATPase incubated for 15 mins by ADP Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM163115(US9062026, Table III, Compound 43)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM163115(US9062026, Table III, Compound 43)
Affinity DataIC50: 9.15E+3nMAssay Description:Inhibition of p97 ATPase in human A549 cells assessed as accumulation of CHOP poly-ubiquitinated proteins incubated for 6 hrs by immunofluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM163115(US9062026, Table III, Compound 43)
Affinity DataIC50: 1.53E+4nMAssay Description:Inhibition of p97 ATPase in human A549 cells assessed as accumulation of K48 poly-ubiquitinated proteins incubated for 6 hrs by immunofluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed