BDBM163297 US9687479, 213 3-(5-[(5-chlorothiophen-2-yl)methyl]amino-1-[4-(morpholin-4-yl)phenyl]carbonyl-1H-pyrazol-3-yl)-1-(pyridin-3-ylmethyl)-1,2-dihydropyridin-2-one

SMILES Clc1ccc(CNc2cc(nn2C(=O)c2ccc(cc2)N2CCOCC2)-c2cccn(Cc3cccnc3)c2=O)s1

InChI Key InChIKey=ADSGNGOCCAOAPO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 163297   

TargetProthrombin(Human)
Verseon

US Patent
LigandPNGBDBM163297(US9687479, 213 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:Human thrombin was obtained from Haematologic Technologies Inc. The chromogenic substrate S-2238 was obtained from DiaPharma. Thrombin was assayed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Verseon

US Patent
LigandPNGBDBM163297(US9687479, 213 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 550nMpH: 7.4 T: 2°CAssay Description:Human KLKB1 protein was obtained from Enzyme Research Labs. The chromogenic substrate S-2302 was obtained from DiaPharma. KLKB1 was assayed in buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Verseon

US Patent
LigandPNGBDBM163297(US9687479, 213 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent