BDBM165363 US8168651, Compound TABLE 16.30::US9062043, Table 13, Compound 30::US9062043, Table 20b, Compound 21

SMILES OC(=O)c1ccc2c(c1)nc(NCCc1cccc(Cl)c1)c1ccncc21

InChI Key InChIKey=CKWLPIWZGQPVEB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 165363   

TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Senhwa Biosciences

US Patent
LigandPNGBDBM165363(US8168651, Compound TABLE 16.30 | US9062043, Table...)
Affinity DataIC50:  640nMpH: 7.4Assay Description:The human leukemia Jurkat T-cell line was maintained in RPMI 1640 (Cambrex) supplemented with 10% fetal calf serum and 50 ng/ml Geutamycin. Before tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Senhwa Biosciences

US Patent
LigandPNGBDBM165363(US8168651, Compound TABLE 16.30 | US9062043, Table...)
Affinity DataIC50:  5nMpH: 7.2Assay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase II subunit alpha'(Homo sapiens (Human))TBA
LigandPNGBDBM165363(US8168651, Compound TABLE 16.30 | US9062043, Table...)
Affinity DataIC50:  17nMAssay Description:Inhibition of C-terminal Nano-Luc fused human CK2alpha' expressed in HEK293 cells using NanoBRET NanoGlo substrate in presence of tracer K5 by NanoBR...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Senhwa Biosciences

US Patent
LigandPNGBDBM165363(US8168651, Compound TABLE 16.30 | US9062043, Table...)
Affinity DataIC50:  230nMAssay Description:Inhibition of C-terminal Nano-Luc fused human CK2alpha expressed in HEK293 cells using NanoBRET NanoGlo substrate in presence of tracer K10 by NanoBR...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Senhwa Biosciences

US Patent
LigandPNGBDBM165363(US8168651, Compound TABLE 16.30 | US9062043, Table...)
Affinity DataIC50:  5nMAssay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair
In DepthDetails US Patent