BDBM166702 5-(4-chlorophenyl)-3-[5-hydroxy-4-pyrone-2-yl-methylmercapto]-4-amino-1,2,4-triazole (6j)

SMILES Nn1c(SCc2cc(=O)c(O)co2)nnc1-c1ccc(Cl)cc1

InChI Key InChIKey=UUEJPLGMTKZLBQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 166702   

TargetPolyphenol oxidase 4(Agaricus bisporus)
University of Health Sciences

Curated by ChEMBL
LigandPNGBDBM166702(5-(4-chlorophenyl)-3-[5-hydroxy-4-pyrone-2-yl-meth...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM166702(5-(4-chlorophenyl)-3-[5-hydroxy-4-pyrone-2-yl-meth...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPolyphenol oxidase 4(Agaricus bisporus)
University of Health Sciences

Curated by ChEMBL
LigandPNGBDBM166702(5-(4-chlorophenyl)-3-[5-hydroxy-4-pyrone-2-yl-meth...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of mushroom Tyrosinase by using L-DOPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetUncharacterized protein YOR062C(Baker's yeast)
Hunan University of Science and Technology

LigandPNGBDBM166702(5-(4-chlorophenyl)-3-[5-hydroxy-4-pyrone-2-yl-meth...)
Affinity DataIC50: 4.50E+3nMpH: 6.8Assay Description:The synthesized compounds were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substrate. Mushroom ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details Article
PubMed