BDBM168221 US9669031, 50 N-[6-[(8-chloro-4′,4′-difluoro-1,5-dioxo-spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide (Cpd. No. 50)::US9669031, 99 6-[(6-aminopyrimidin-4-yl)amino]-8-chloro-4′,4′-difluoro-spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-1,5-dione hydrochloride (Cpd. No. 99)

SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21

InChI Key InChIKey=WUCBMAZIUGCYRG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 168221   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168221(US9669031, 99 6-[(6-aminopyrimidin-4-yl)amino]-8-c...)
Affinity DataIC50: 10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168221(US9669031, 99 6-[(6-aminopyrimidin-4-yl)amino]-8-c...)
Affinity DataIC50: 10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168221(US9669031, 99 6-[(6-aminopyrimidin-4-yl)amino]-8-c...)
Affinity DataIC50: 10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM168221(US9669031, 99 6-[(6-aminopyrimidin-4-yl)amino]-8-c...)
Affinity DataIC50: 10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent