BDBM17032 (3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indole-5-carboxylic acid::CHEMBL107225::Indolinone based inhibitor, 3d

SMILES OC(=O)c1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1

InChI Key InChIKey=AAUBJZPZEKVWOC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 17032   

TargetSerine/threonine-protein kinase tousled-like 2(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM17032(CHEMBL107225 | (3Z)-2-oxo-3-(1H-pyrrol-2-ylmethyli...)
Affinity DataIC50: 62nMAssay Description:Inhibition of human TLK2 preincubated for 20 mins followed by 33P-ATP addition and measured after 120 mins by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17032(CHEMBL107225 | (3Z)-2-oxo-3-(1H-pyrrol-2-ylmethyli...)
Affinity DataIC50: 213nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Berlex Biosciences

LigandPNGBDBM17032(CHEMBL107225 | (3Z)-2-oxo-3-(1H-pyrrol-2-ylmethyli...)
Affinity DataIC50: 260nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2007
Entry Details Article
PubMed