BDBM174032 US9688661, 2-(5-Chloro-2-ethylphenyl)-N-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-3-carboxamide (compd 303)

SMILES CCc1ccc(Cl)cc1-c1c(cc(-c2ncnc3[nH]ccc23)n1C)C(N)=O

InChI Key InChIKey=RVVQRAIDFSCSGG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 174032   

TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174032(US9688661, 2-(5-Chloro-2-ethylphenyl)-N-methyl-5-(...)
Affinity DataIC50: 1nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [861-1152](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174032(US9688661, 2-(5-Chloro-2-ethylphenyl)-N-methyl-5-(...)
Affinity DataIC50: 6nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174032(US9688661, 2-(5-Chloro-2-ethylphenyl)-N-methyl-5-(...)
Affinity DataIC50: 12nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent