BDBM174146 US9688669, Example 19::US9688669, Example 20::US9688669, Example 21

SMILES CCC(O)CC#Cc1cncc(c1)[C@H]1NC(=O)O[C@@H]1c1cccc(F)c1

InChI Key InChIKey=HPCWBLWTSKYMKP-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 174146   

TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM174146(US9688669, Example 19 | US9688669, Example 20 | US...)
Affinity DataEC50:  28nMAssay Description:HEK293 (ZF) cells stably transfected with human mGluR5A (pIRES neo) and the rat glutamate-aspartate transporter (GLAST; pIRES puro) are grown in a mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM174146(US9688669, Example 19 | US9688669, Example 20 | US...)
Affinity DataEC50:  30nMAssay Description:HEK293 (ZF) cells stably transfected with human mGluR5A (pIRES neo) and the rat glutamate-aspartate transporter (GLAST; pIRES puro) are grown in a mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM174146(US9688669, Example 19 | US9688669, Example 20 | US...)
Affinity DataEC50:  61nMAssay Description:HEK293 (ZF) cells stably transfected with human mGluR5A (pIRES neo) and the rat glutamate-aspartate transporter (GLAST; pIRES puro) are grown in a mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent