BDBM174790 US10053462, 21::US9102686, 21::US9540388, 21

SMILES Fc1cnc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1ccc(Cl)cc1Cl

InChI Key

Data  5 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 174790   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174790(US9102686, 21 | US9540388, 21 | US10053462, 21)
Affinity DataKi:  50nM IC50: 4.40nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174790(US9102686, 21 | US9540388, 21 | US10053462, 21)
Affinity DataKi:  50nM IC50: 3.35E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174790(US9102686, 21 | US9540388, 21 | US10053462, 21)
Affinity DataKi:  50nM IC50: 95nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174790(US9102686, 21 | US9540388, 21 | US10053462, 21)
Affinity DataKi:  50.1nMAssay Description:Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174790(US9102686, 21 | US9540388, 21 | US10053462, 21)
Affinity DataKi:  50.1nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174790(US9102686, 21 | US9540388, 21 | US10053462, 21)
Affinity DataIC50: 94.8nMpH: 7.4Assay Description:Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174790(US9102686, 21 | US9540388, 21 | US10053462, 21)
Affinity DataIC50: 94.8nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174790(US9102686, 21 | US9540388, 21 | US10053462, 21)
Affinity DataIC50: 3.35E+3nMpH: 7.4Assay Description:Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174790(US9102686, 21 | US9540388, 21 | US10053462, 21)
Affinity DataIC50: 3.35E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent