BDBM175097 US9115116, 6a

SMILES C[C@@H]1C[C@H](OC(=O)Nc2ccc(cc2)C#C)[C@@H]2[C@@H](CC[C@@H]3C[C@H](CC(=O)O3)O[Si](C)(C)C(C)(C)C)[C@@H](C)C=CC2=C1

InChI Key InChIKey=HWWVAOJWOSZHRO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 175097   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
National Taiwan University

US Patent
LigandPNGBDBM175097(US9115116, 6a)
Affinity DataIC50: 36.5nMpH: 7.4Assay Description:The HMGR activity was performed using HMG-CoA reductase assay kit from Sigma-Aldrich with the human recombinant protein or 100 μg total cell lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
National Taiwan University

US Patent
LigandPNGBDBM175097(US9115116, 6a)
Affinity DataIC50: 127nMT: 2°CAssay Description:The HDAC activity was performed using the HDAC fluorescent activity assay kit (BIOMOL, Plymouth Meeting, Pa., USA) according to the manufacturer'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
National Taiwan University

US Patent
LigandPNGBDBM175097(US9115116, 6a)
Affinity DataIC50: 159nMT: 2°CAssay Description:The HDAC activity was performed using the HDAC fluorescent activity assay kit (BIOMOL, Plymouth Meeting, Pa., USA) according to the manufacturer'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
National Taiwan University

US Patent
LigandPNGBDBM175097(US9115116, 6a)
Affinity DataIC50: 463nMT: 2°CAssay Description:The HDAC activity was performed using the HDAC fluorescent activity assay kit (BIOMOL, Plymouth Meeting, Pa., USA) according to the manufacturer'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
US Patent