BDBM176563 US9120756, 25

SMILES C[C@@H](C(=O)NCc1cc(nn1-c1cccc(Cl)c1)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1

InChI Key InChIKey=REFSKWWRGFCGDO-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 176563   

LigandPNGBDBM176563(US9120756, 25)
Affinity DataKi:  5.10nMAssay Description:The agonistic or antagonistic effect of the substances to be tested on the rat-species vanilloid receptor 1 (VR1/TRPV1) can be determined using the f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

LigandPNGBDBM176563(US9120756, 25)
Affinity DataKi:  26.5nM ΔG°:  -10.7kcal/moleT: 2°CAssay Description:The agonistic or antagonistic effect of the substances to be tested on the vanilloid receptor 1 (VR1) can also be determined using the following assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent

LigandPNGBDBM176563(US9120756, 25)
Affinity DataKi:  27nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced intracellular calcium level preincubated for 6 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM176563(US9120756, 25)
Affinity DataIC50: 2.59E+3nMT: 2°CAssay Description:The agonistic or antagonistic effect of the substances to be tested on the vanilloid receptor 1 (VR1) can also be determined using the following assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
US Patent