BDBM180073 US9676721, 98 2-cyano-3-(pyridin-4-yl)-1-{[4-(quinoline-6-sulfonyl)phenyl]methyl}guanidine

SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1ccc2ncccc2c1

InChI Key InChIKey=HOHNAIIWDWJNAB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 180073   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandChemical structure of BindingDB Monomer ID 180073BDBM180073(US9676721, 98 2-cyano-3-(pyridin-4-yl)-1-{[4-(quin...)
Affinity DataIC50: 6.20nMpH: 7.5 T: 2°CAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent