BDBM18264 6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::CHEMBL420172::Pyrrolo[2, 3-d]pyrimidine analogue, 1d

SMILES Cc1c(Sc2ccc(Cl)cc2)[nH]c2nc(N)nc(N)c12

InChI Key InChIKey=PDRGTQJDCURYCI-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 18264   

TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

LigandPNGBDBM18264(6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 4.00E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

LigandPNGBDBM18264(6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from Mycobacterium avium (Mycobacterium avium)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM18264(6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 8.93E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM18264(6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 8.93E+3nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM18264(6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 8.93E+3nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (Toxoplasma gondii)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18264(6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of Dihydrofolate reductase from Pneumocystis carinii (Pneumocystis carinii)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18264(6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 1.67E+4nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

LigandPNGBDBM18264(6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 1.90E+4nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

LigandPNGBDBM18264(6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

LigandPNGBDBM18264(6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of rat liver DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed