BDBM183200 US9150546, I-364::US9688643, I-364::US9718790, I-0364

SMILES CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F

InChI Key InChIKey=CAYYASMSWISXDA-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 183200   

TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 30nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded in a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 30nMAssay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683)) was used. The cells were seeded...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2018
Entry Details
US Patent

TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683)) was used. The cells were seeded...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at human P2X3 receptor expressed in rat C6-BU-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetP2X purinoceptor 2/3(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 2.37E+3nMAssay Description:Antagonist activity at human P2X2/3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetP2X purinoceptor 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human P2X1 receptor expressed in rat C6-BU-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human P2X2 receptor expressed in rat C6-BU-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human P2X4 receptor expressed in rat C6-BU-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM183200(US9688643, I-364 | US9718790, I-0364 | US9150546, ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed