BDBM18915 2-{4-[3-bromo-4-(2-methylpropanamido)phenoxy]-3,5-dichlorophenyl}acetic acid::4-amido bioisosteric ligand, 12b

SMILES CC(C)C(=O)Nc1ccc(Oc2c(Cl)cc(CC(O)=O)cc2Cl)cc1Br

InChI Key InChIKey=HHSRCUBLBZYJPA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18915   

TargetThyroid hormone receptor beta(Human)
Karo Bio

LigandPNGBDBM18915(2-{4-[3-bromo-4-(2-methylpropanamido)phenoxy]-3,5-...)
Affinity DataIC50: 18nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Karo Bio

LigandPNGBDBM18915(2-{4-[3-bromo-4-(2-methylpropanamido)phenoxy]-3,5-...)
Affinity DataIC50: 18.2nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Karo Bio

LigandPNGBDBM18915(2-{4-[3-bromo-4-(2-methylpropanamido)phenoxy]-3,5-...)
Affinity DataIC50: 18.2nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Karo Bio

LigandPNGBDBM18915(2-{4-[3-bromo-4-(2-methylpropanamido)phenoxy]-3,5-...)
Affinity DataIC50: 630nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Karo Bio

LigandPNGBDBM18915(2-{4-[3-bromo-4-(2-methylpropanamido)phenoxy]-3,5-...)
Affinity DataIC50: 631nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed