BDBM18917 2-{4-[3-bromo-4-(2-methylpentanamido)phenoxy]-3,5-dichlorophenyl}acetic acid::4-amido bioisosteric ligand, 12d

SMILES CCCC(C)C(=O)Nc1ccc(Oc2c(Cl)cc(CC(O)=O)cc2Cl)cc1Br

InChI Key InChIKey=QBMDICSETMGEGS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18917   

TargetThyroid hormone receptor beta(Human)
University of Insubria

Curated by ChEMBL
LigandPNGBDBM18917(2-{4-[3-bromo-4-(2-methylpentanamido)phenoxy]-3,5-...)
Affinity DataIC50: 46.8nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of Insubria

Curated by ChEMBL
LigandPNGBDBM18917(2-{4-[3-bromo-4-(2-methylpentanamido)phenoxy]-3,5-...)
Affinity DataIC50: 46.8nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
University of Insubria

Curated by ChEMBL
LigandPNGBDBM18917(2-{4-[3-bromo-4-(2-methylpentanamido)phenoxy]-3,5-...)
Affinity DataIC50: 47nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18917(2-{4-[3-bromo-4-(2-methylpentanamido)phenoxy]-3,5-...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM18917(2-{4-[3-bromo-4-(2-methylpentanamido)phenoxy]-3,5-...)
Affinity DataIC50: 1.30E+3nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2007
Entry Details Article
PubMed