BDBM189428 US9174974, Example 13

SMILES CC[C@@H](C(O)=O)c1ccc2NC(=O)OC[C@H](C)c3ccc(cc3C)[C@@H](Nc3ccc4c(N)ncc(F)c4c3)C(=O)N(C)Cc1c2

InChI Key InChIKey=WLAIPSALBVRAPW-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 189428   

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189428(US9174974, Example 13)
Affinity DataKi:  0.610nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189428(US9174974, Example 13)
Affinity DataKi:  380nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent