BDBM194717 US10174030, Example 103::US10717737, Example 103::US11247992, Example 103::US9670210, Example 103 2-(4-{[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]carbonyl}-1H-pyrazol-1-yl)ethanol

SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C(=O)c1cnn(CCO)c1

InChI Key InChIKey=QMACINFHUYISJD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 194717   

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM194717(US9670210, Example 103 2-(4-{[4-(methoxymethyl)-4-...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM194717(US9670210, Example 103 2-(4-{[4-(methoxymethyl)-4-...)
Affinity DataIC50: 100nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM194717(US9670210, Example 103 2-(4-{[4-(methoxymethyl)-4-...)
Affinity DataIC50: 100nMAssay Description:LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM194717(US9670210, Example 103 2-(4-{[4-(methoxymethyl)-4-...)
Affinity DataIC50: 100nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
US Patent