BDBM194820 US9206184, 1::US9206184, 2

SMILES COCc1c(CN2CCNC(=O)C2)n2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1

InChI Key InChIKey=HNLRRJSKGXOYNO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 194820   

TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant FGFR2 in the presence of ATP at 0.8 uM measured after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 7.20nMpH: 7.0 T: 2°CAssay Description:For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 12.2nMpH: 7.0 T: 2°CAssay Description:For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant FGFR1 in the presence of ATP at 0.16 uM measured after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant FGFR3 in the presence of ATP at 0.8 uM measured after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 24.8nMpH: 7.0 T: 2°CAssay Description:For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 29.4nMpH: 7.0 T: 2°CAssay Description:For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant FGFR4 in the presence of ATP at 0.8 uM measured after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed