BDBM195945 US9206199, 50

SMILES COc1ccc([C@@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2ccc(nc2)-n2cnnn2)c(C)c1[N+]#[C-]

InChI Key InChIKey=NIGHEYXVVCPVJO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 195945   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195945(US9206199, 50)
Affinity DataIC50: 80nMAssay Description:The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195945(US9206199, 50)
Affinity DataIC50: 130nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2016
Entry Details
US Patent