BDBM19647 (2R)-2-(cyclohexylmethyl)-4-(morpholin-4-yl)-4-oxo-N-[(2S)-4-phenyl-1-{[4-(trifluoromethoxy)phenyl]amino}butan-2-yl]butanamide::succinamide peptidomimetic, 13

SMILES FC(F)(F)Oc1ccc(NC[C@H](CCc2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC(=O)N2CCOCC2)cc1

InChI Key InChIKey=IRBSFNODBMYMJG-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19647   

TargetCathepsin S(Human)
Gnf

LigandPNGBDBM19647((2R)-2-(cyclohexylmethyl)-4-(morpholin-4-yl)-4-oxo...)
Affinity DataKi:  18nM ΔG°:  -11.0kcal/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Gnf

LigandPNGBDBM19647((2R)-2-(cyclohexylmethyl)-4-(morpholin-4-yl)-4-oxo...)
Affinity DataKi:  636nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin K(Human)
Gnf

LigandPNGBDBM19647((2R)-2-(cyclohexylmethyl)-4-(morpholin-4-yl)-4-oxo...)
Affinity DataKi:  1.48E+3nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed