BDBM19648 (2R)-2-(cyclohexylmethyl)-4-(morpholin-4-yl)-4-oxo-N-[(1S)-1-phenyl-2-{[4-(trifluoromethoxy)phenyl]amino}ethyl]butanamide::succinamide peptidomimetic, 14

SMILES FC(F)(F)Oc1ccc(NC[C@@H](NC(=O)[C@H](CC2CCCCC2)CC(=O)N2CCOCC2)c2ccccc2)cc1

InChI Key InChIKey=GXSRBNHUUSSGMZ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19648   

TargetCathepsin S(Human)
Gnf

LigandPNGBDBM19648((2R)-2-(cyclohexylmethyl)-4-(morpholin-4-yl)-4-oxo...)
Affinity DataKi:  62nM ΔG°:  -10.2kcal/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Gnf

LigandPNGBDBM19648((2R)-2-(cyclohexylmethyl)-4-(morpholin-4-yl)-4-oxo...)
Affinity DataKi:  3.52E+3nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed
TargetCathepsin K(Human)
Gnf

LigandPNGBDBM19648((2R)-2-(cyclohexylmethyl)-4-(morpholin-4-yl)-4-oxo...)
Affinity DataKi: >3.00E+4nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2007
Entry Details Article
PubMed