BDBM196531 US9670214, TABLE 14.10

SMILES COC1CCN(CC1)C(=O)c1ccc2c(Nc3ccc(OC(F)(F)F)cc3)ncnc2c1

InChI Key InChIKey=KPUWMDDBRXWOKP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 196531   

TargetNon-specific protein-tyrosine kinase(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM196531(US9670214, TABLE 14.10)
Affinity DataIC50: 639nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM196531(US9670214, TABLE 14.10)
Affinity DataIC50: 895nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent