BDBM19901 (1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-(4-{4-[(fluoromethyl)sulfanyl]phenyl}pyridin-3-yl)cyclohexane-1-carboxamide::beta-substituted cyclohexanecarboxamide, 2

SMILES FCSc1ccc(cc1)-c1ccncc1[C@@H]1CCC(F)(F)C[C@H]1C(=O)NCC#N

InChI Key InChIKey=GJOBCXRHMCXBRY-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19901   

TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19901((1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-(4-{4-[(flu...)
Affinity DataIC50: 2nM EC50:  58nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2008
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19901((1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-(4-{4-[(flu...)
Affinity DataIC50: 2nM EC50:  58nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2008
Entry Details Article
PubMed