BDBM19904 4-[(1R,2R)-2-[(cyanomethyl)carbamoyl]-4,4-difluorocyclohexyl]-3-[4-(methylsulfanyl)phenyl]-1-pyridin-1-olate::beta-substituted cyclohexanecarboxamide, 5

SMILES CSc3ccc(c1c[n+]([O-])ccc1[C@@H]2CCC(F)(F)C[C@H]2C(=O)NCC#N)cc3

InChI Key InChIKey=VCBDFTWLPGEPSD-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19904   

TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19904(4-[(1R,2R)-2-[(cyanomethyl)carbamoyl]-4,4-difluoro...)
Affinity DataIC50: 5nM EC50:  75nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2008
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19904(4-[(1R,2R)-2-[(cyanomethyl)carbamoyl]-4,4-difluoro...)
Affinity DataIC50: 5nM EC50:  75nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2008
Entry Details Article
PubMed